Formulation and Evaluation of Multiparticulate Systems of Rifampicin and Isoniazid with Improved Rifampicin Stability
نویسنده
چکیده
Methods: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release pellets of Rifampicin and enteric coated pellets of Isoniazid. These pellets were evaluated for various physicochemical parameters. Enteric coating was mainly done to prevent the release of Isoniazid in acidic medium and to improve the stability of Rifampicin by preventing their interaction in stomach. Dissolution studies for both these formulations were performed and the cumulative percentage drug release for Rifampicin was calculated.
منابع مشابه
Formulation and Evaluation Ofenteric Coated Pellets of Rifampicin and Isoniazid with Improved Rifampicin Stability
Objective: The aim of the present study is to formulate and evaluate enteric coated pellets of Rifampicin and Isoniazid with improved Rifampicin stability in invitro conditions. Methodology: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release enteric coate...
متن کاملFormulation and Evaluation of Fixed Dose Combination Products of Rifampicin and Isoniazid with Improved Rifampicin Stability
Introduction: One of the main reasons for the development of the resistance in the therapy for Tuberculosis is the mono drug therapy. This may be due to the drug-drug interactions as the therapy includes combination of various drugs leading to poor bioavailability of these drugs. One such reported interaction is between Rifampicin and Isoniazid which leads to poor bioavailability of Rifampicin....
متن کاملSimultaneous spectrophotometric determination of Rifampicin, Isoniazid and Pyrazinamide in a single step
Three antituberculosis medications are investigated in this work consist of rifampicin, isoniazid and pyrazinamide. The ultra violet (UV) spectra of these compounds are overlapped, thus use of suitable chemometric methods are helpful for simultaneous spectrophotometric determination of them. A generalized version of net analyte signal standard addition method (GNASSAM) was used for determinatio...
متن کاملSimultaneous spectrophotometric determination of Rifampicin, Isoniazid and Pyrazinamide in a single step
Three antituberculosis medications are investigated in this work consist of rifampicin, isoniazid and pyrazinamide. The ultra violet (UV) spectra of these compounds are overlapped, thus use of suitable chemometric methods are helpful for simultaneous spectrophotometric determination of them. A generalized version of net analyte signal standard addition method (GNASSAM) was used for determinatio...
متن کاملTuberculosis chemotherapy: current drug delivery approaches
Tuberculosis is a leading killer of young adults worldwide and the global scourge of multi-drug resistant tuberculosis is reaching epidemic proportions. It is endemic in most developing countries and resurgent in developed and developing countries with high rates of human immunodeficiency virus infection. This article reviews the current situation in terms of drug delivery approaches for tuberc...
متن کامل